RESEARCH PUBLICATIONS

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Toli-Nørrelykke, S., A. Engh, R. Landick, and J. Gelles. 2003. Diversity in the rates of transcript elongation by single RNA polymerase molecules. J. Biol. Chem,, in press. abstract

Shaevitz, J. W., E. A. Abbondanzieri, R. Landick and S. M. Block^.2003. Backtracking by single RNA polymerase molecules observed at near-basepair resolution. Nature 426: 684-687. abstract

Mooney, R. A., and R. Landick. 2003. Tethering s⁷⁰ to RNA polymerase reveals high in vivo activity of s factors and s⁷⁰-dependent pausing at promoter-distal location, Genes Dev. 17, 2839-2851. abstract

Neuman, K., E. A. Abbondanzieri, R. Landick, J. Gelles, and S. M. Block^.2003. Ubiquitous transcriptional pausing is independent of RNA polymerase backtracking. Cell 115, 437-447. abstract

Toulokhonov, I, and R. Landick. 2003. The flap domain is required for pause RNA hairpin inhibition of catalysis by RNA polymerase and can modulate intrinsic termination. Mol. Cell 12, 1125-1136. abstract

Wilson, K. A., M. Kalkum, J. Ottesen, J. Yuzunkova, B. T. Chait, R. Landick, T. Muir, K. Severinov, and S. Darst. 2003. The structure of microcin J25, a peptide inhibitor of bacterial RNA polymerase, is a lassoed tail., J. Am. Chem. Soc. 125, 12475-12483. abstract

Artsimovitch, I., C. Chu, S. Lynch, and R. Landick. 2003. A new class of bacterial RNA polymerase inhibitor affects nucleotide addition. Science 302, 650-654. abstract full text and pdf link

Santangelo, T., R. Mooney, R. Landick, and J.W. Roberts. 2003. RNA Polymerase mutations that impair reconfiguration to a termination resistant complex by Q antiterminator proteins. Genes Dev 17: 1281-1292. abstract

Artsimovitch, I, V. Svetlov, K. S. Murakami, and R. Landick. 2003. Co-overexpression of E. coli RNA polymerase subunits allows isolation and analysis of mutant enzymes lacking lineage-specific sequence insertions, J. Biol. Chem. 278, 12344-12355. abstract

Yuzenkova, J., M. Delgado, S. Nechaev, D. Savalia, V. Epshtein, I. Artsimovitch, R. Mooney, R. Landick, R. N. Farrias, R. Salomon, and K. Severinov. 2002. Mutations of bacterial RNA polymerase leading to resistance to microcin J25. J Biol Chem. 277, 50867-50875.

Ederth, J., I. Artsimovitch, L. Isaksson, and R. Landick. 2002. The downstream DNA jaw of bacterial RNA polymerase facilitates both transcriptional initiation and pausing. J. Biol. Chem. 277, 37456-37463.

Artsimovitch, I, and R. Landick. 2002. The transcriptional regulator RfaH stimulates RNA chain synthesis after recruitment to elongation complexes by the exposed nontemplate DNA strand, Cell 109, 193-203.

Palangat, M., and R. Landick. 2001. Roles of RNA:DNA hybrid stability, RNA structure, and active site conformation in nonequilibrium pausing by human RNA polymerase II, J. Mol. Biol. 311, 265-282.

Gruber, T. M., D. Markov, M. M. Sharp, B. A. Young, C. Z. Lui, H. J. Zhong, I. Artsimovitch, K. M. Geszvain, R. Landick, K. Severinov, and C. A. Gross. 2001. Binding of the initiation factor s⁷⁰ to core RNA polymerase is a multistep process. Mol. Cell. 8, 21-31.

Toulokhonov, I., I. Artsimovitch, and R. Landick. 2001. Allosteric control of RNA polymerase by an interaction site for nascent RNA hairpins, Science 292, 730-733.

Artsimovitch, I., V. Svetlov, L. Anthony, R. R. Burgess, and R. Landick. 2000. RNA polymerases from Bacillus subtilis and Escherichia coli differ in recognition of regulatory signals in vitro. J Bacteriol 182, 6027-6035.

Anthony, L. C., I. Artsimovitch, V. Svetlov, R. Landick and R. R. Burgess. 2000. Rapid purification of His(6)-tagged Bacillus subtilis core RNA polymerase. Protein Expr. Purif. 19, 350-354.

Artsimovitch, I, and R. Landick. 2000. Pausing by bacterial RNA polymerase is mediated by mechanistically distinct classes of signals, Proc. Natl.Acad. Sci. USA. 13, 7090-7095.

Davenport, R. J., G. J. L. Wuite, R. Landick, and C. Bustamante. 2000. Single molecule study of transcriptional pausing and arrest by E. coli RNA polymerase. Science, 287, 2497-2500.

Opalka, N., R. A. Mooney, C. Richter, K.Severinov, R. Landick and S. A. Darst. 2000. Direct localization of a b subunit domain on the three-dimensional structure of Escherichia coli RNA polymerase,. Proc. Natl.Acad. Sci. USA 97, 617-622.

Yin, H., I. Artsimovitch, R. Landick and J. Gelles. 1999. Non-equilibrium mechanism of transcription termination from observations of single RNA polymerase molecules, Proc. Natl. Acad. Sci. USA 96, 13124-13129.

Keene, R. G., A. Mueller, R. Landick and L. London. 1999. Transcriptional pause, arrest, and termination sites for RNA polymerase II in mammalian N- and c-myc genes. Nucleic Acids Res. 27, 3173-3182.

Pan, T., I. Artsimovitch, R. Landick, and T. Sosnick. 1999. Folding of a large ribozyme during transcription and the effect of the elongation factor NusA. Proc. Natl.Acad. Sci. USA 96, 9545-9550.

Wang, M. D., M. J. Schnitzer, H. Yin, R. Landick, J. Gelles, and S. M. Block. 1998. Force and velocity measured for single molecules of RNA polymerase. Science 282, 902-907.

Artsimovitch, I., and R. Landick. 1998. A nascent RNA hairpin stimulates transcriptional pausing through direct interaction with RNA polymerase, but transcript release by competition for other interactions, Genes Dev.,12, 3110-3122.

Palangat, M., T. I. Meier, R. G. Keene and R. Landick. 1998. Transcriptional pausing at +62 of the HIV-1 nascent RNA modulates formation of the TAR RNA structure. Mol. Cell, 1, 1033-1042.

Serverinov, K., R. Mooney, S. A. Darst and R. Landick. 1997. Tethering of the large subunits of Escherichia coli RNA polymerase. J. Biol. Chem., 272, 24137-24140.

Wang, D., K. Severinov, and R. Landick. 1997. A nascent RNA hairpin that stimulates transcriptional pausing interacts with RNA polymerase near amino acid 909 of the ß subunit, Proc. Natl.Acad. Sci. USA, 94, 8483-8488.

Wang, M., H. Yin, R. Landick, J. Gelles and S. Block. 1997. Stretching DNA with optical tweezers. Biophys. J., 72, 1335-1346.

Chan, C. L., D. Wang and R. Landick. 1997. Multiple interactions stabilize a single paused transcription intermediate in which hairpin to 3’ end spacing distinguishes pause and termination pathways, J. Mol. Biol., 268, 54-68.

Chan, C. L., and R. Landick. 1997. Effects of neutral salts on transcript elongation and pausing, J. Mol. Biol., 268, 37-53.

Wang, D., and Landick, R. 1997. Nuclease cleavage of the upstream half of the nontemplate strand DNA in an Esecherichia coli transcripiton elongation complex causes upstream translocation and transcriptional arrest,J. Biol. Chem., 272, 5989-5994.

Tavromina, P. L., R. Landick and C. A. Gross. 1996. Isolation, purification, and in vitro characterization of recessive-lethal-mutant RNA polymerases from Escherichia coli, J. Bacteriol.,178, 5263-5371.

Heisler, L. M., G. Feng, D. J. Jin, C. A. Gross, and R. Landick,. 1996. Amino acid substitutions in the two largest subunits of Escherihcia coli RNA polymerase that suppress a Defective Rho termination factor affect different parts of the transcription complex, J. Biol. Chem., 271, 14572-14583.

Yin, H., M. D. Wang, K. Svoboda, R. Landick, S. M. Block and J. Gelles. 1995. Transcription against an applied force, Science, 270, 1653-1657.

Severinov, K., D. Markov, E. Severinova, V. Nikiforov, R. Landick, S. A. Darst, and A. Goldfarb. 1995. Streptolydigin-resistant mutants in an evolutionarily conserved region of the ß' subunit of Escherichia coli RNA polymerase. J. Biol. Chem., 270, 23926-23929.

Severinov, K., A. Mustaev, E. Severinova, I. Bass, R. Landick, V. Nikiforov, A. Goldfarb, and S. A. Darst. 1995. Assembly of functional Escherichia coli RNA polymerase using ß-subunit fragments, Proc. Natl. Acad. Sci. U. S. A., 92, 4591-4595.

Wang, D., T. I. Meier, C. L. Chan, G. Feng, D. N. Lee and R. Landick. 1995. Discontinuous movements of DNA and RNA in E. coli RNA polymerase accompany formation of a paused transcription complex, Cell., 81, 341-350.

Yin, H., R. Landick and J. Gelles. 1994. Tethered particle motion method for studying transcript elongation by a single RNA polymerase molecule, Biophys. J., 67, 2468-2478.

Weilbaecher, R., C. Hebron, G. Feng and R. Landick. 1994. Amino acid changes in the ß'-subunit of E. coli RNA polymerase alter transcriptional pausing and termination, Genes Dev. 8, 2913-2927.

Darst, S. A., C. E. Stebbins, S. Borukhov, M. Orlova, G. Feng, R. Landick and A. Goldfarb. 1994. Crystallization of GreA, a transcript cleavage factor from Escherichia coli.J. Mol. Biol., 242, 582-585.

Lee, D. N., G. Feng and R. Landick. 1994. GreA-induced transcript cleavage is accompanied by reverse translocation to a new transcription complex conformation, J. Biol. Chem., 269, 22295-22303.

Feng, G., D. N. Lee, D. Wang, C. L. Chan and R. Landick. 1994. GreA-induced transcript cleavage in transcirption complexes containing E. coli RNA polymerase is controlled by multiple factors, including nascent transcript location and structure, J. Biol. Chem., 269, 22282-22294.

Heisler, L. M., H. Suzuki, R Landick and C. A. Gross. 1993. Four contiguous amino acids define the target for streptolydigin resistance in the ß subunit of Escherichia coli RNA polymerase. J. Biol. Chem. 268, 25369-25375.

Chan, C. L., and R. Landick. 1993. Dissection of the his leader pause site by base substitution reveals a multipartite signal that includes a pause RNA hairpin, J. Mol. Biol. 233, 25-42.

Lee, D. N., and R. Landick. 1992. Structure of RNA and DNA chains in paused transcription complexes containing Escherichia coli RNA polymerase, J. Mol. Biol. 228, 759-777.

London, L., R. G. Keene and R. Landick. 1991. Analysis of premature termination in c-myc during transcription by RNA polymerase II in a HeLa nuclear extract. Mol. Cell. Biol. 11, 4599-4615.

Schafer, D., J. Gelles, M. Sheetz and R. Landick. 1991. Transcription by single molecules of RNA polymerase observed by video microscopy. Nature 352, 444-448.

Landick, R., C. Yanofsky, L. Phung and K. Choo. 1990. Replacement of the Escherichia coli trp attenuator control codons alters operon expression, J. Mol. Biol. 216, 25-37.

Landick, R., J. Stewart and D. N. Lee. 1990. Amino acid changes in conserved regions of the ß-subunit of Escherichia coli RNA polymerase alter transcription pausing and termination, Genes and Devel. 4, 1623-1636.

Lee, D. N., L. Phung, J. Stewart and R. Landick. 1990. Transcription pausing by Escherichia coli RNA polymerase is modulated by downstream DNA sequences, J. Biol. Chem. 265, 15145-15153.

Adams, M. D., L. M. Wagner, T. M. Graddis, R. Landick, T. K. Antonucci, A. L. Gibson and D. L. Oxender. 1990. Nucleotide sequence and genetic characterization reveal six essential genes for the LIV-I and LS transport systems of Escherichia coli, J. Biol. Chem. 265, 11436-11443.

Landick, R., A. Colwell and J. Stewart. 1990. Insertional mutagenesis of a plasmid-borne E. coli rpoB gene reveals alterations that inhibit ß-subunit assembly into RNA Polymerase, J. Bacteriol. 172, 2844-2854.

Chan, C. and R. Landick. 1989. The S. typhimurium his operon leader region contains an RNA hairpin-dependent transcription pause site: mechanistic implications of the effect on pausing of altered RNA hairpins, J. Biol. Chem. 264, 20796-20804.

Ti-zhi, S., B. R. Copeland, R. Landick, J. T. Graddis, and D. L. Oxender. 1988. Export of hybrid proteins of leucine-specific binding protein and trypotophan synthetase in Escherichia coli, Acta Biochim. Biophys. Sinica 20, 364-370.

Landick, R., and C. Yanofsky. 1987. Structural analysis of the E. coli trp leader paused transcription complex, J. Mol. Biol. 196, 363-377.

Landick, R., J. Carey, and C. Yanofsky. 1987. Detection of transcription pausing in vivo in the trp operon leader region, Proc. Natl. Acad. Sci. USA 84, 1507-1511.

Nazos, P.M., T. K. Antonucci, R. Landick, and D. L. Oxender. 1986. Cloning and characterization of livH, the structural gene encoding a membrane component of the leucine transport system in Escherichia coli, J. Bacteriol. 166, 565-573.

Stewart, V., R. Landick, and C. Yanofsky. 1986. Rho-dependent in vitro transcription of the E. coli tryptophanase operon leader region of Escherichia coli K-12, J. Bacteriol. 166, 217-233.

Antonucci, T.K., R. Landick, and D. L. Oxender. 1985. The leucine binding proteins of Escherichia coli as models for studying the relationships between protein structure and function, J. Cellular Biochem. 29, 209-216.

Landick, R., J. Carey, and C. Yanofsky. 1985. Translation activates the paused transcription complex and restores transcription of the trp operon leader region, Proc. Natl. Acad. Sci. USA 82, 4663-4667.

Landick, R., and D. L. Oxender. 1985. The complete nucleotide sequences of the E. coli LIV-BP and LS-BP genes: implications for the mechanism of the LIV-I transport system, J. Biol. Chem. 260, 8257-8261.

Landick, R., D. Maguire, and L. C. Lutter,. 1984. Optimization of polyacrylamide gel electrophoresis conditions used for sequencing mixed oligodeoxyribonucleotides, DNA 3, 414-419.

Landick, R., V. Vaughn, E. T. Lau, R. A. VanBogelen, J. W. Erickson, and F. C. Neidhardt 1984. Nucleotide sequence of the heat shock regulatory gene of E. coli suggests its protein may be a transcription factor, Cell 38, 175-182.

Landick, R., and C. Yanofsky. 1984. Stability of an RNA secondary structure affects in vitro transcription pausing in the trp operon leader region, J. Biol. Chem. 259, 11550-11555.

Copeland, B.R., R. Landick, P. M. Nazos, and D. L. Oxender. 1984. Role of membrane potential in protein folding and domain formation during secretion in Escherichia coli, J. Cell. Biochem. 24, 345-356.

Landick, R., J. R. Duncan, B. R. Copeland, P. M. Nazos, and D. L. Oxender. 1984. Secretion and degradation of mutant leucine-specific binding protein molecules containing C-terminal deletions, J. Cell. Biochem. 24, 331-344.

Daniels, C.J., J. J. Anderson, R. Landick, and D. L. Oxender. 1981. The in vitro synthesis and processing of the branched-chain amino acid binding proteins, J. Supramol. Struct. 14, 305-311.

Landick, R., J. J. Anderson, M. M. Mayo, R. P. Gunsalus, P. Mavromara, C. J. Daniels, and D. L. Oxender. 1981. Regulation of the high-affinity leucine transport genes of E. coli, J. Supramol. Struct. 14, 527-537.

Oxender, D.L., J. J. Anderson, C. J. Daniels, R. Landick, R. P. Gunsalus, G. Zurawski, and C. Yanofsky. 1980. Amino-terminal sequence and processing of the precursor of the leucine-specific binding protein, and evidence for conformational differences between the precursor and mature form, Proc. Natl. Acad. Sci. USA 77, 2005-2009.

Oxender, D.L., J. J. Anderson, C. J. Daniels, R. Landick, R. P. Gunsalus, G. Zurawski, E. Selker, and C. Yanofsky. 1980. Organization and expression of cloned genes for the high-affinity leucine transport system of E. coli, Proc. Natl. Acad. Sci. USA 77, 1412-1416.

Marino, J.P., and R. C. Landick. 1975. 1-Phenylthiocyclopropyl-triphenylphosphonium fluroborate: A new synthon for cyclopentanone synthesis, Tetrahedron Letters 51, 4531-4534.

REVIEWS AND BOOK CHAPTERS

Geszvain, K. M., and R. Landick. 2003. Structure of RNA polymerase. In The Bacterial Chromosome (N. P. Higgins, ed.), American Society for Microbiology, Washington, D. C, in press.

Landick, R. 2001. RNA polymerase clamps down. Cell. 105, 567-570.

R. A. Mooney and R. Landick. 1999. RNA polymerase unveiled. Cell 98, 1-4.

R. Landick. 1999. Shifting RNA polymerase into overdrive. Science, 284, 598-599.

R. A. Mooney, I. Artsimovitch and R. Landick. 1998. Information processing by RNA polymerase: recognition of regulatory signals during RNA chain elongation. J. Bacteriol. 180, 3265-3275.

J. Gelles and R. Landick. 1998. RNA polymerase as a molecular motor. Cell, 93, 13-16.

R. Landick. 1997. RNA polymerase slides home: pause and termination site recognition. Cell, 88, 741-744.

R. Landick and J. W. Roberts. 1996. The shrewd grasp of RNA polymerase. Science 273, 202-203.

Landick, R., D. Wang, and C. L. Chan. 1996. Quantitative analysis of transcriptional pausing by RNA polymerase: the his leader pause site as a paradigm. Methods Enzymol. 274 (S. Adhya, ed.), 334-353.

Landick, R., C. Turnbough, Jr., and C. Yanofsky. 1996. Transcription attenuation. In Escherichia coli and Salmonella: Cellular and Molecular Biology , 2nd Edition (F.C. Neidhardt, R. Curtiss III, J.L. Ingraham, K.R. Low, B. Magasanik, Schaechter, M., and H.E. Umbarger, eds.), pp. 1263-1286, American Society for Microbiology, Washington, D. C.

Chan, C. L., and R. Landick. 1994. New perspectives on transcript elongation and termination by E. coli RNA polymerase. In Transcription: Mechanisms and Regulation (J. W. Conaway, R. C. Conaway , eds.), pp. 297-321, Raven Press, New York.

Landick, R., and C. Turnbough, Jr. 1992. Transcriptional attenuation. In Transcriptional Regulation (S. L. McKnight and K. R. Yamamoto, eds.), pp. 407-446, Cold Spring Harbor Press, Cold Spring Harbor, N. Y.

Landick, R.C. 1987. The Role of the paused transcription complex in trp operon attenuation. In RNA polymerase and the Regulation of Transcription. A Steenbock Symposium (W.S. Reznikoff, R.R. Burgess, J.E. Dahlberg, C.A. Gross, M.T. Record, and M.P. Wickens, eds.), pp. 441-444, Elsevier, New York.

Landick, R., and C. Yanofsky. 1987. Transcription attenuation. In Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology (F.C. Neidhardt, J.L. Ingraham, K.R. Low, B. Magasanik, Schaechter, M., and H.E. Umbarger, eds.), pp. 1276-1301, American Society for Microbiology, Washington, D. C.

Landick, R., D. L. Oxender, and G. F.-L. Ames. 1985. Bacterial amino acid transport systems. In The Enzymes of Biological Membranes, 2nd Edition, Vol. 3 (A. Martonosi, ed.), pp. 577-615, Plenum Press, New York.

Landick, R. 1984. Regulation of LIV-I transport system gene expression. In Microbiology 1984 (L. Leive and D. Schlessinger, eds.), pp. 71-74, American Society for Microbiology, Washington, D. C.

Oxender, D.L., R. Landick, P. Nazos, and B. R. Copeland. 1984. The role of membrane potential in protein folding and secretion in Escherichia coli. In Microbiology 1984 (L. Leive and D. Schlessinger, eds.), pp. 4-7, American Society for Microbiology, Washington, D. C.

Nazos, P.M., T. Z. Su, R. Landick, and D. L. Oxender, 1984. Branched-chain amino acid transport in Escherichia coli. In Microbiology 1984 (L. Leive and D. Schlessinger, eds.) pp. 24-28, American Society for Microbiology, Washington, D. C.

Copeland, B. R., R. Landick, P. M. Nazos, and D. L. Oxender. 1984. role of membrane potential in protein folding and domain formation during secretion in Escherichia coli. In Protein Transport and Secretion (D. Oxender, ed.), pp. 279-290, Alan Liss Inc., New York.

Landick, R., C. J. Daniels, and D. L. Oxender. 1983. Insertion of Proteins in Bacterial Membranes, In Methods in Enzymology, Vol. 97, Biomembranes, Part K, Membrane Biogenesis: Assembly and Targeting (Prokaryotes, Mitochondria, and Chloroplasts) (S. Fleischer and B. Fleischer, Eds.), pp. 146-153, Academic Press, New York.

Landick, R., and D. L. Oxender. 1982. Bacterial periplasmic binding proteins. In Membranes and Transport: A Critical Review, Vol. 2 (A. Martonosi, ed.), pp. 81-91, Plenum Press, New York.

Daniels, C.J., J. J. Anderson, R. Landick, and D. L. Oxender. 1981. The in vitro synthesis and processing of the branched-chain amino acid binding proteins. In Progress in Clinical and Biochemical Research, Membrane Transport, and Neuroreceptors (A. Blume, I. Diamond, D. Oxender, and C.F. Fox, eds.), pp. 319-325, Alan Liss Inc., New York.

Landick, R., J. J. Anderson, M. M. Mayo, R. P. Gunsalus, P. Mavromara, C. J. Daniels, and D. L. Oxender. 1981. Regulation of the high-affinity leucine transport genes of E. coli. In Progress in Clinical and Biochemical Research, Membrane Transport, and Neuroreceptors (A. Blume, I. Diamond, D. Oxender, and C.F. Fox, eds.), pp. 343-353, Alan Liss Inc., New York.